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Downloadable Research Documentation

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 Published Studies for the Efficacy of Allograft Tissue Products Derived from Birth Tissue (Wharton’s Jelly)

  1. Comparative Characterization of Cells from the Various Compartments of the Human Umbilical Cord Shows that the Wharton’s Jelly Compartment Provides the Best Source of Clinically Utilizable Mesenchymal Stem Cells

  2. Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC

  3. Umbilical Cord Tissue Offers the Greatest Number of Harvestable Mesenchymal Stem Cells for Research and Clinical Application: A Literature Review of Different Harvest Sites

  4. Rapid biomimetic mineralization of collagen fibrils and combining with human umbilical cord mesenchymal stem cells for bone defects healing

  5. The umbilical cord matrix is a better source of mesenchymal stem cells (MSC) than the umbilical cord blood

  6. Umbilical Cord Tissue Offers the Greatest Number of Harvestable Mesenchymal Stem Cells for Research and Clinical Application: A Literature Review of Different Harvest Sites

  7. Discarded Wharton’s Jelly of the Human Umbilical Cord: A Viable Source for Mesenchymal Stem Cells

  8. Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy

  9. Human Umbilical Cord-Derived Mesenchymal Stem Cells Do Not Undergo Malignant Transformation during Long-Term Culturing in Serum-Free Medium

 10. Batsali, A. Comparative Analysis of Bone Marrow and Wharton’s Jelly Mesenchymal Stem/Stromal Cells. Blood.
2013:122:1212.

 11. Batsali, AK et.al. Mesenchymal stem cells derived from Wharton’s Jelly of the umbilical cord: biological properties and
emerging clinical applications. Current Stem Cell Research and Therapeutics. 2-13 Mar: 8(2): 144-55.

 12. DiMarino, A. et.al. Mesenchymal Stem Cells in Tissue Repair. Frontiers in Immunology. 2013;4:201.

 13. Doi, H. et.al. Potency of umbilical cord blood- and Wharton’s jelly-derived mesenchymal stem cells for scarless wound
healing Scientific Reports 6 :18844(2016).

 14. F Gao et.al. Mesenchymal stem cells and immunomodulation: current status and future prospects Cell Death and
Disease (2016) 7, e2062; doi:10.1038/cddis.2015.327.

 15. Hye, J. et.al. Comparative Analysis of Human Mesenchymal Stem Cells from Bone Marrow, Adipose Tissue, and
Umbilical Cord Blood as Sources of Cell Therapy. International Journal of Molecular Science 2013 Sep: 14(9):
17986-18001.

 16. Hsieh J-Y, Wang H-W, Chang S-J, Liao K-H, Lee I-H, Lin W-S, et al. (2013) Mesenchymal Stem Cells from Human
Umbilical Cord Express Preferentially Secreted Factors Related to Neuroprotection, Neurogenesis, and Angiogenesis.
PLoS ONE 8(8): e72604. doi:10.1371/journal.pone.007260

 17. Kalaszczynska, I and Ferdyn, K. Wharton’s Jelly Derived Mesenchymal Stem Cells: Future of Regenerative Medicine?
BioMed Research International. Vol 2015 article ID 430847.

 18. Liu, Y. et.al. Therapeutic Potential of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Rheumatoid
Arthritis. Arthritis Research and Therapeutics. 2010; 12(6): R 210.

 19. Murphy, M. et.al. Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine.
Experimental and Molecular Medicine. 2013 Nov; 48(1) e54.

 20. Sobolewski, K. et.al. Wharton’s jelly as a reservoir of peptide growth factors. Placenta. 2005 Nov;26(10):747-52.

 21. Watson, N. et.al. Discarded Wharton’s Jelly of the Human Umbilical Cord: A Viable Source for Mesenchymal Stem
Cells. Cytotherapy. 2015 January; 17(1): 18-24.

 22. Ye, B. et.al. Rapid biomimetic mineralization of collagen fibrils and combining with human umbilical cord mesenchymal
stem cells for bone defects healing. Material Science and Engineering C Material Biology Appl. 2016 Nov 1, 68:
43-51.

 23. Bellamy, et al. Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev.
2006 Apr 19;(2):CD005321

 24. Didier Demesmin, MD Amniotic Fluid as a Homologue to Synovial Fluid: Interim Analysis of Prospective, Multi-Center
Outcome Observational Cohort Registry of Amniotic Fluid Treatment for Osteoarthritis of the Knee Presented at the
2015 AAPM Annual Meeting

 25. Brohlin, et. al, Characterisation of human mesenchymal stem cells following differentiation into Schwann cell-like
cells. Neuroscience Research. 2009, 64(1):41-49.

 26. Chaudhury, S. Mesenchymal stem cell applications to tendon healing. Muscles Ligaments Tendons J. 2012 Jul-Sep;
2(3): 222–229.

 27. Udalamaththa, V. et.al. Potential Role of Herbal Remedies in Stem Cell Therapy: Proliferation and Differentiation of
Human Mesenchymal Stromal Cells Stem Cell Research and Therapy. (2016) 7:110.

 28. Aleynik , et. al. Stem cell delivery of therapies for brain disorders. Clinical and Translational Medicine 2014, 3:24

 29. Li, et. al, Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under
xeno-free conditions for cell therapy. Stem Cell Res Ther. 2015; 6(1): 55.

 30. Anzalone R, et al. Wharton’s jelly mesenchymal stem cells as candidates for beta cells regeneration: extending the
differentiation and immunomodulatory benefits of adult mesenchymal stem cells for the treatment of type 1 diabetes.
Stem Cell Rev. 2011; 7(2):342-63.

 31. Tesche LJ, Gerber DA. Tissue-derived stem and progenitor cells. Stem cells international. 2010; 2010:824876.

 32. Kalaszczynska, et. al, Wharton’s Jelly Derived Mesenchymal Stem Cells: Future of Regenerative Medicine? Recent
Findings and Clinical Significance. Biomed Res Int. 2015; 2015: 430847

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